1195. Bezafibrate

Nomenclature

CAS number: 41859-67-0
2-[4-[2-[(4-Chlorobenzoyl)amino]ethyl]phenoxy]-2-methylpropanoic acid; 2-[p-[2-(p-chlorobenzamido)ethyl]phenoxy]-2-methylpropionic acid; α-[4-(4-chlorobenzoylaminoethyl)phenoxy]isobutyric acid; BM-15075; Befizal (Oberval); Bezalip (Boehringer, Mann.); Bezatol (Kissei); Cedur (Boehringer, Mann.); Difaterol (Andreu).
C19H20ClNO4; mol wt 361.82.
C 63.07%, H 5.57%, Cl 9.80%, N 3.87%, O 17.69%.

Description and references

Prepn: E. Witte et al., DE 2149070; eidem, US 3781328 (both 1973 to Boehringer, Mann.). Pharmacology: R. Zimmerman et al., Atherosclerosis 29, 477 (1978). Clinical studies: A. G. Olsson, P. D. Lang, ibid. 31, 421, 429 (1978); P. Wahl et al., Dtsch. Med. Wochenschr. 103, 1233 (1978). Review of pharmacodynamics and therapeutic use: J. P. Monk, P. A. Todd, Drugs 33, 539-576 (1987).

Chemical structure

Properties

Crystals from acetone, mp 186°.

Therapeutic Category

Antilipemic.

Keywords

Antilipemic; Fibrates