1240. Biricodar

Nomenclature

CAS number: 159997-94-1
(2S)-1-[Oxo(3,4,5-trimethoxyphenyl)acetyl]-2-piperidinecarboxylic acid 4-(3-pyridinyl)-1-[3-(3-pyridinyl)propyl]butyl ester.
C34H41N3O7; mol wt 603.71.
C 67.64%, H 6.85%, N 6.96%, O 18.55%.

Description and references

Chemosensitizer that restores sensitivity to cytotoxic agents in multidrug resistant (MDR) cells. Prepn: D. M. Armistead et al., WO 9407858; eidem, US 5620971 (1994, 1997 both to Vertex). Effect on MDR mediated by P-glycoprotein: U. A. Germann et al., Anti-Cancer Drugs 8, 125 (1997); by multidrug resistance-associated protein (MRP): eidem, ibid. 141. Clinical pharmacology, pharmacokinetics: E. K. Rowinsky et al., J. Clin. Oncol. 16, 2964 (1998).

Chemical structure

Derivative

Dicitrate.

Nomenclature

CAS number: 174254-13-8
VX-710; Incel (Vertex).
C34H41N3O7.2C6H8O7; mol wt 987.95.
C 55.92%, H 5.82%, N 4.25%, O 34.01%.

Properties

Sol in water.

Therapeutic Category

Antineoplastic adjunct (chemosensitizer).

Keywords

Antineoplastic Adjunct; Chemosensitizer