1296. Bisoxatin Acetate

Nomenclature

CAS number: 14008-48-1
2,2-Bis[4-(acetyloxy)phenyl]-2H-1,4-benzoxazin-3(4H)-one; 2,2-bis(4-acetoxyphenyl)-3-oxo-2,3-dihydrobenz-1,4-oxazine; Wy-8138; Laxonalin; Maratan (Ravizza); Talsis (Wyeth); Tasis (Wyeth).
C24H19NO6; mol wt 417.41.
C 69.06%, H 4.59%, N 3.36%, O 23.00%.

Description and references

Prepd from 2,2-dichloro-3-oxo-2,3-dihydrobenz-1,4-oxazine and phenylacetate or by acetylation of the diphenol: Seeger, US 3006917 (1961 to Thomae). Toxicity: E. I. Goldenthal, Toxicol. Appl. Pharmacol. 18, 185 (1971).

Chemical structure

Properties

Crystals from ethanol, mp 190°. LD50 orally in rats, mice: 8000, >10,000 mg/kg (Goldenthal).

Therapeutic Category

Cathartic.

Keywords

Laxative/Cathartic