1333. Bopindolol
Nomenclature
CAS number: 62658-63-3
1-[(1,1-Dimethylethyl)amino]-3-[(2-methyl-1H-indol-4-yl)oxy]-2-propanol
benzoate ester; (±)-1-(tert-butylamino)-3-[(2-methylindol-4-yl)oxy]-2-propanol
benzoate (ester). C23H28N2O3; mol wt 380.48.
C 72.60%, H 7.42%, N 7.36%, O 12.62%.
Description and references
Nonselective β-adrenergic blocker. Prepn: F. Troxler, F. Seemann, DE 2635209; eidem, US 4340541 (1977, 1982 both to Sandoz). Clinical pharmacology: P. van Brummelen et al., Eur. J. Clin. Pharmacol. 22, 491 (1982). HPLC determn in plasma: C. J. Oddie et al., J. Chromatogr. 273, 469 (1983). Effect on plasma lipid fractions: P. van Brummelen et al., Br. J. Clin. Pharmacol. 17, 86 (1984). Pharmacokinetics: R. Platzer et al., Clin. Pharmacol. Ther. 36, 5 (1984). Clinical trials in hypertension: U. L. Hulthen et al., J. Cardiovasc. Pharmacol. 5, 426 (1983); W. J. Schiess et al., Eur. J. Clin. Pharmacol. 27, 529 (1984).
Properties
Sol in ether, methylene chloride. LD50 i.v. in mice: 17 mg/kg (Troxler, Seemann, 1977).Derivative
Maleate.Nomenclature
CAS number: 62658-64-4
Sandonorm (Novartis). C23H28N2O3.C4H4O4; mol wt 496.55.
C 65.31%, H 6.50%, N 5.64%, O 22.55%.
Derivative
Malonate.Nomenclature
CAS number: 82857-38-3
LT-31-200; Wandonorm (Novartis). C23H28N2O3.C3H4O4; mol wt 484.54.
C 64.45%, H 6.66%, N 5.78%, O 23.11%.
Therapeutic Category
Antihypertensive.
Keywords
β-Adrenergic Blocker; Antihypertensive; Aryloxypropanolamine Derivatives