1417. Bromodichloromethane

Nomenclature

CAS number: 75-27-4
Dichlorobromomethane; BDCM; NCI-C55243.
CHBrCl2; mol wt 163.83.
C 7.33%, H 0.62%, Br 48.77%, Cl 43.28%.

Description and references

Trihalomethane contaminant found in chlorinated water. Prepn: O. Jacobsen, R. Neumeister, Ber. 15, 599 (1882); M. Fedorynski et al., Synth. Commun. 7, 287 (1977). Disposition and metabolism: J. M. Mathews et al., J. Toxicol. Environ. Health 30, 15 (1990). Toxicity studies: F. J. Bowman et al., Toxicol. Appl. Pharmacol. 44, 213 (1978); Y. Aida et al., J. Toxicol. Sci. 17, 51 (1992). Review of quantitative analyses, toxicity and carcinogenicity: IARC Monographs 52, 179-212 (1991); of toxicology and human exposure: Toxicological Profile for Bromodichloromethane (PB90-167461, 1989) 89 pp.

Properties

Colorless liquid. bp 88.4-88.6° (Fedorynski); also reported as bp 91-92° (Jacobsen). d15 1.9254. nD20 1.4967. LD50 in male, female mice (mg/kg): 450, 900 orally (Bowman).

Caution

Potential symptoms of acute oral overexposure in animals are liver and kidney damage; CNS depression, incoordination, sleepiness, lethargy, sedation. Chronic exposure has been associated with cancer of liver, kidney and intestines. See: Toxicological Profile for Bromodichloromethane (PB90-167461, 1989) 77 pp. This substance is reasonably anticipated to be a human carcinogen: Report on Carcinogens, Eleventh Edition (PB2005-104914, 2004) p III-35.

Use

Chemical reagent, intermediate in organic synthesis.