1464. Buclizine

Nomenclature

CAS number: 82-95-1
1-[(4-Chlorophenyl)phenylmethyl]-4-[[4-(1,1-dimethylethyl)phenyl]methyl]piperazine; 1-(p-tert-butylbenzyl)-4-(p-chloro-α-phenylbenzyl)piperazine; 1-(p-chlorobenzhydryl)-4-(p-tert-butylbenzyl)diethylenediamine; 1-(p-tert-butylbenzyl)-4-(p-chlorodiphenylmethyl)piperazine; histabutyzine; histabutizine.
C28H33ClN2; mol wt 433.03.
C 77.66%, H 7.68%, Cl 8.19%, N 6.47%.

Description and references

Prepn: Morren, US 2709169 (1955 to U.C.B.), see also DE 964040, Lui et al., C.A. 62, 2776a (1965). Clinical evaluation as antiemetic in migraine: P. B. Jorgensen et al., Curr. Ther. Res. 16, 1276 (1974); E. I. Adam, J. Int. Med. Res. 15, 71 (1987).

Chemical structure

Properties

bp0.001 217-220°.

Derivative

Dihydrochloride.

Nomenclature

CAS number: 129-74-8
UCB-4445; Aphilan (UCB); Buclina (Sanofi-Synthelabo); Longifene (UCB); Postafen (UCB).
C28H33ClN2.2HCl; mol wt 505.95.
C 66.47%, H 6.97%, Cl 21.02%, N 5.54%.

Properties

mp 230-240°.

Therapeutic Category

Antiemetic.

Keywords

Antiemetic