1469. Budipine

Nomenclature

CAS number: 57982-78-2
1-(1,1-Dimethylethyl)-4,4-diphenylpiperidine; 1-tert-butyl-4,4-diphenylpiperidine.
C21H27N; mol wt 293.45.
C 85.95%, H 9.27%, N 4.77%.

Description and references

Centrally acting deriv of diphenylpiperidine. Prepn: H. G. Menge, J. Klosa, DE 1936452; eidem, US 4016280 (1969, 1977 both to Byk Gulden). Pharmacological studies: U. Brand, H. G. Menge, Arzneim.-Forsch. 30, 1242 (1980); M. Eltze, ibid. 1129; H. G. Menge, U. Brand, ibid. 32, 85 (1982). Comparison to other drugs in treatment of dyskinesias: J. Siegfried, Can. J. Neurol. Sci. 6, 89 (1979). Clinical evaluation with levodopa in Parkinson's disease: K. Jellinger, H. Bliesath, J. Neurol. 234, 280 (1987).

Chemical structure

Derivative

Hydrochloride.

Nomenclature

CAS number: 63661-61-0
Parkinsan (Byk Gulden).
C21H27N.HCl; mol wt 329.91.
C 76.45%, H 8.55%, N 4.25%, Cl 10.75%.

Properties

LD50 in male mice, rats (mg/kg): 120, 165 orally; 33, 28 i.v. (Menge, Brand).

Therapeutic Category

Antiparkinsonian.

Keywords

Antiparkinsonian