1474. Bufexamac

Nomenclature

CAS number: 2438-72-4
4-Butoxy-N-hydroxybenzeneacetamide; 2-(p-butoxyphenyl)acetohydroxamic acid; 2-[p-(butyloxy)phenyl]acetohydroxamic acid; CP-1044-J3; Droxarol (Pharmos); Droxaryl (Continental Pharma); Feximac (Nicholas); Malipuran (Heumann); Mofenar (C.E.P.A.); Norfemac (HMR); Parfenac (Lederle); Parfenal (Cyanamid).
C12H17NO3; mol wt 223.27.
C 64.55%, H 7.67%, N 6.27%, O 21.50%.

Description and references

Synthesis: N. P. Buu-Ho et al., Compt. Rend. 261, 2259 (1965); eidem, BE 661226; eidem, US 3479396 (1965, 1969 to Madan). Pharmacology and toxicology: Lambelin et al., Med. Pharmacol. Exp. 15, 545 (1966).

Chemical structure

Properties

Needles from acetone, mp 153-155°. Practically insol in water. LD50 orally in mice, rats: >8, >4 g/kg (Lambelin).

Therapeutic Category

Anti-inflammatory.

Keywords

Anti-inflammatory (Nonsteroidal); Arylacetic Acid Derivatives