1473. Bufetolol

Nomenclature

CAS number: 53684-49-4
1-[(1,1-Dimethylethyl)amino]-3-[2-[(tetrahydro-2-furanyl)methoxy]phenoxy]-2-propanol; 1-(tert-butylamino)-3-[o-[(tetrahydrofurfuryl)oxy]phenoxy]-2-propanol.
C18H29NO4; mol wt 323.43.
C 66.84%, H 9.04%, N 4.33%, O 19.79%.

Description and references

β-Adrenergic blocker. Prepn: M. Nakanishi et al., DE 2024001; eidem, US 3723476 (1970, 1973, both to Yoshitomi); eidem, J. Med. Chem. 15, 45 (1972). Pharmacology: M. Nakanishi et al., Yakugaku Zasshi 91, 1037 (1971); ibid. 92, 375 (1972); Imamura et al., ibid. 1039. Metabolism: M. Nakanishi et al., ibid. 299; Oyo Yakuri 6, 479 (1972), C.A. 78, 66785b (1973). Toxicology: eidem, ibid. 485, 1267, C.A. 78, 66945d; 79, 337w (1973).

Chemical structure

Properties

bp0.07 180-186°.

Derivative

Hydrochloride.

Nomenclature

CAS number: 35108-88-4
Y-6124; Adobiol (Yoshitomi).
C18H29NO4.HCl; mol wt 359.89.
C 60.07%, H 8.40%, N 3.89%, O 17.78%, Cl 9.85%.

Properties

White crystals from methanol-isopropanol, mp 153.5-157°; also reported as mp 151-154°. (Diastereoisomer, mp 118°). Freely sol in water, methanol, glacial acetic acid. Very slightly sol in benzene. Practically insol in ether. Unstable on exposure to light.

Therapeutic Category

Antiarrhythmic; antianginal.

Keywords

β-Adrenergic Blocker; Antianginal; Antiarrhythmic