1517. Butedronic Acid

Nomenclature

CAS number: 51395-42-7
(Diphosphonomethyl)butanedioic acid; (diphosphonomethyl)succinic acid; 2,3-dicarboxypropane-1,1-diphosphonic acid; DPD.
C5H10O10P2; mol wt 292.07.
C 20.56%, H 3.45%, O 54.78%, P 21.21%.

Description and references

Prepn: A. Heins et al., DE 2217692 (1973 to Henkel); eidem, US 3923876 (1975 to Bayer A.G.); K. H. Worms, H. Blum, Z. Anorg. Allg. Chem. 457, 219 (1979); and physical-chemical properties: N. Vanlic-Razumenic et al., J. Serb. Chem. Soc. 51, 63 (1986). Clinical pharmacokinetics of 99mTc complex: C. Schümichen, H. Schmidt, Nuklearmedizin Suppl. 19, 930 (1982). Clinical evaluation of 99mTc complex as skeletal imaging agent: G. Godart et al., Clin. Nucl. Med. 11, 92 (1986).

Chemical structure

Derivative

Monohydrate.

Properties

White crystalline powder from glacial acetic acid and water (15:1), mp 150°. uv max (water): 208 nm (ε 274).

Derivative

Tetrasodium salt.

Nomenclature

CAS number: 97772-98-0
Tc-924 (DPD); Teceos (Hoechst Roussel).
C5H6Na4O10P2; mol wt 380.00.
C 15.80%, H 1.59%, Na 24.20%, O 42.10%, P 16.30%.

Therapeutic Category

99mTc complex as diagnostic aid (radioactive imaging agent).

Keywords

Butedronic Acid Complex with 99mTc: Diagnostic Aid (Radioactive Imaging Agent)