1524. Buthalital Sodium

Nomenclature

CAS number: 510-90-7
Dihydro-5-(2-methylpropyl)-5-(2-propenyl)-2-thioxo-4,6(1H,5H)-pyrimidinedione monosodium salt; 5-allyl-5-isobutyl-2-thiobarbituric acid sodium salt; sodium 5-allyl-5-isobutyl-2-thiobarbiturate; 5-allyl-5-(2-methylpropyl)-2-thiobarbituric acid sodium salt; thialbutone sodium; Baytinal (Bayer); Buthalitone Sodium; Thialisobumalnatrium; Transithal (M & B); Ulbreval.
C11H15N2NaO2S; mol wt 262.30.
C 50.37%, H 5.76%, N 10.68%, Na 8.76%, O 12.20%, S 12.22%.

Description and references

Prepn: Miller et al., J. Am. Chem. Soc. 58, 1090 (1936). Pharmacology: Schildt, Schildt, Acta Pharmacol. Toxicol. 19, 377 (1962).

Chemical structure

Properties

Pale yellow, hygroscopic powder. Freely sol in water, yielding alkaline solns. Partly sol in ethanol. Insol in ether, benzene.

Derivative

Free acid.

Nomenclature

CAS number: 468-65-5
C11H16N2O2S; mol wt 240.32.
C 54.98%, H 6.71%, N 11.66%, O 13.32%, S 13.34%.

Properties

Crystals, mp 147°.

Note

This is a controlled substance (depressant): 21 CFR, 1308.13.

Therapeutic Category

Anesthetic (intravenous).

Keywords

Anesthetic (Intravenous)