1599. Buzepide

Nomenclature

CAS number: 3691-21-2
Hexahydro-α,α-diphenyl-1H-azepine-1-butanamide; 2,2-diphenyl-4-hexamethyleneiminobutyramide; R-658.
C22H28N2O; mol wt 336.47.
C 78.53%, H 8.39%, N 8.33%, O 4.76%.

Description and references

Anticholinergic. Prepn: Janssen et al., J. Med. Pharm. Chem. 1, 187 (1959); of methiodide as well as free base: Janssen, de Jongh, US 2881165 (1959 to N.V. Nederlandsche Combinatie Chem. Ind.). Clinical trial in irritable bowel syndrome: J. Ph. Barbier et al., Ann. Gastroenterol. Hepatol. 25, 123 (1989).

Chemical structure

Properties

Crystals from isopropanol, mp 141.5-143.5°.

Derivative

Methiodide.

Nomenclature

CAS number: 15351-05-0
Metazepium iodide; 1-(3-carbamoyl-3,3-diphenylpropyl)hexahydro-1-methylazepinium iodide; N-(3,3-diphenyl-3-carbamoylpropyl)-N-methylperhydroazepinium iodide; diphexamide methiodide.
C22H28N2O.CH3I; mol wt 478.41.
C 57.74%, H 6.53%, N 5.86%, O 3.34%, I 26.53%.

Properties

Crystals, dec 212-213°.

Derivative

Mixture with haloperidol.

Nomenclature

Vésadol (Janssen).

Therapeutic Category

Antispasmodic.

Keywords

Antimuscarinic; Antispasmodic