12-01486. Bucloxic Acid [Archived]

Nomenclature

CAS number: 32808-51-8
3-Chloro-4-cyclohexyl-α-oxobenzenebutanoic acid; 3-(3-chloro-4-cyclohexylbenzoyl)propionic acid; 4-(4-cyclohexyl-3-chlorophenyl)-4-oxobutyric acid; bucloxonic acid.
C16H19ClO3; mol wt 294.77.
C 65.19%, H 6.50%, Cl 12.03%, O 16.28%.

Description and references

Prepn: Krausz, Brunaud, DE 2021445 (1970 to Clin-Byla), C.A. 75, 5521d (1971); GB 1315542; Krausz et al., Arzneim.-Forsch. 24, 1360, 1364 (1974). Series of articles on pharmacology, metabolism, toxicity: ibid. 1368-1444. Toxicology: G. Mauzé et al., ibid. 1398.

Chemical structure

Properties

Crystals from acetone, mp 163°. uv max (ethanol): 255 nm (ε 15,500). LD50 in mice, rats (mg/kg): 900, 120 orally; 1100, 210 i.p (Krausz, p. 1360).

Derivative

Calcium salt.

Nomenclature

CAS number: 32808-53-0
CB-804; Esfar.
C32H36CaCl2O6; mol wt 627.61.
C 61.24%, H 5.78%, Ca 6.39%, Cl 11.30%, O 15.30%.

Properties

LD50 in male, female mice, rats (mg/kg): 1558, 1697, 195, 600-900 i.p.; 852, 1656, 176, 649 orally (Mauzé).

Therapeutic Category

Anti-inflammatory.

Keywords

Anti-inflammatory (Nonsteroidal); Arylpropionic Acid Derivatives

Status

This monograph has been retired and is no longer subject to revision or update.