1646. Calcium Acetate

Nomenclature

CAS number: 62-54-4
Acetic acid calcium salt (2:1); Phos-ex (Vitaline); PhosLo (Nabi).
C4H6CaO4; mol wt 158.17.
C 30.37%, H 3.82%, Ca 25.34%, O 40.46%.
Ca(CH3COO)2.

Description and references

The technical product was originally known as brown acetate of lime or gray acetate of lime. Prepn and analysis of acetate of lime: Stillwell, Gladding, J. Am. Chem. Soc. 4, 94 (1882); T. S. Gladding, Ind. Eng. Chem. 1, 250 (1909). Distillation to produce acetone: E. G. R. Ardagh et al., ibid. 16, 1133 (1924). Electrolytic prepn: H. Schmidt, Z. Anorg. Allg. Chem. 270, 188 (1952). Analysis of hydrated forms: J. Panzer, J. Chem. Eng. Data 7, 140 (1962). Toxicity study: Smyth et al., Am. Ind. Hyg. Assoc. J. 30, 470 (1969). Clinical evaluation in hyperphosphatemia: W. Y. Qunibi et al., Kidney Int. 65, 1914 (2004).

Properties

Very hygroscopic, rod-shaped crystals. On heating above 160° dec to acetone and CaCO3. d 1.50. Sol in water; slightly sol in methanol. Practically insol in ethanol, acetone, benzene. Keep well closed.

Derivative

Monohydrate.

Nomenclature

CAS number: 5743-26-0
C4H6CaO4.H2O; mol wt 176.18.
C 27.27%, H 4.58%, Ca 22.75%, O 45.41%.

Properties

Needles, granules or powder. Does not lose all its water below 150°. Sol in water; slightly sol in alcohol. pH of 0.2 molar aq soln 7.6. LD50 orally in rats: 4.28 g/kg (Smyth).

Use

Manuf of acetic acid, acetone; in dyeing, tanning, and curing skins; in lubricants; as food stabilizer; as corrosion inhibitor. Monohydrate used in precipitation of oxalates.

Therapeutic Category

Antihyperphosphatemic.

Keywords

Antihyperphosphatemic