1647. Calcium Acetylsalicylate

Nomenclature

CAS number: 69-46-5
2-(Acetyloxy)benzoic acid calcium salt; salicylic acid acetate calcium salt; acetylsalicylic acid calcium salt; calcium aspirin; soluble aspirin; Cal-Aspirin (Winthrop); Dispril; Disprin; Kalmopyrin; Kalsetal; Solaspin (Indian Health); Tylcalsin.
C18H14CaO8; mol wt 398.38.
C 54.27%, H 3.54%, Ca 10.06%, O 32.13%.
Ca(OOCC6H4OCOCH3)2.

Description and references

Prepd from calcium carbonate and acetylsalicylic acid: Lawrence, US 2003374 (1935 to Lee Labs.).

Derivative

Dihydrate.

Properties

Amorphous, nonhygroscopic powder. One gram dissolves in 6 ml water, 80 ml alcohol.

Derivative

Complex with urea.

Nomenclature

CAS number: 5749-67-7
Carbasalate calcium; acetylsalicylic acid calcium salt complex with urea; calcium acetylsalicylate carbamide; urea calcium acetylsalicylate; carbaspirin calcium; Alcacyl (Novartis); Ascal (Viatris); Calurin (Dorsey); Cardiosolupsan (BMS); Solupsan (UPSA).
C19H18CaN2O9; mol wt 458.43.
C 49.78%, H 3.96%, Ca 8.74%, N 6.11%, O 31.41%.

Description and references

Description and hydrolytic stability: Parrott, J. Pharm. Sci. 51, 897 (1962). Clinical trial in migraine: C. Le Jeunne et al., Eur. Neurol. 41, 37 (1999).

Properties

Amorphous powder, dec 243-245°. Soly in water at 37°: 231 mg/ml, pH 4.8.

Therapeutic Category

Analgesic; antipyretic; anti-inflammatory.

Keywords

Anti-inflammatory (Nonsteroidal); Salicylic Acid Derivatives; Antipyretic; Analgesic; Non-opioids; Salicylic Acid Derivatives