1725. Camazepam

Nomenclature

CAS number: 36104-80-0
Dimethylcarbamic acid 7-chloro-2,3-dihydro-1-methyl-2-oxo-5-phenyl-1H-1,4-benzodiazepin-3-yl ester; 7-chloro-1,3-dihydro-3-hydroxy-1-methyl-5-phenyl-2H-1,4-benzodiazepin-2-one dimethylcarbamate (ester); 7-chloro-1,3-dihydro-3-(N,N-dimethylcarbamoyl)-1-methyl-5-phenyl-2H-1,4-benzodiazepin-2-one; SB-5833; Albego (Boehringer, Ing.).
C19H18ClN3O3; mol wt 371.82.
C 61.37%, H 4.88%, Cl 9.53%, N 11.30%, O 12.91%.

Description and references

Prepn: G. Ferrari, C. Casagrande, DE 2142181; eidem, US 3799920 (1972, 1974 both to Siphar). Metabolism: F. Marcucci et al., J. Pharm. Sci. 67, 1470 (1978). Pharmacology: L. Merlo et al., Arzneim.-Forsch. 24, 1759 (1974); R. Ferrini et al., ibid. 2029. Clinical studies: A. Tammaro et al., ibid. 27, 2177 (1978); S. Carrara et al., Eur. J. Clin. Pharmacol. 13, 335 (1978).

Chemical structure

Properties

White crystalline powder from ethyl acetate, mp 173-174°. Sol in alcohol, moderately sol in water. LD50 in mice, rats (mg/kg): 970, >4000 orally (Ferrini).

Note

This is a controlled substance (depressant): 21 CFR, 1308.14.

Therapeutic Category

Anxiolytic.

Keywords

Anxiolytic; Benzodiazepine Derivatives