1726. Cambendazole

Nomenclature

CAS number: 26097-80-3
[2-(4-Thiazolyl)-1H-benzimidazol-5-yl]carbamic acid 1-methylethyl ester; 2-(4-thiazolyl)-5-benzimidazolecarbamate isopropyl ester; 5-isopropoxycarbonylamino-2-(4-thiazolyl)benzimidazole; 5-isopropoxycarbonylaminothiabendazole; isopropyl 2-(4-thiazolyl)-5-benzimidazolecarbamate; MK-905; Camvet (Merck & Co.); Noviben (Merck & Co.).
C14H14N4O2S; mol wt 302.35.
C 55.61%, H 4.67%, N 18.53%, O 10.58%, S 10.61%.

Description and references

Prepn and activity studies: Hoff, Fisher, ZA 6800351 (1969 to Merck & Co.), C.A. 72, 90461q (1970); Hoff et al., Experientia 26, 550 (1970). Clinical studies with sheep, cattle and swine: Egerton et al., Res. Vet. Sci. 11, 193, 495, 590 (1970).

Chemical structure

Properties

Odorless, white crystalline solid, mp 238-240° (dec). Sol in alcohol, dimethylformamide; sparingly sol in acetone; slightly sol in benzene; very slightly sol in 0.1M HCl. Practically insol in isooctane and water (0.02 mg/ml). Stable in acid and base in range of pH 1 to 12. uv max (0.1N HCl): 319, 232 nm (A1%1cm 740, 670).

Therapeutic Category (Veterinary)

Anthelmintic.