1794. Carbetapentane

Nomenclature

CAS number: 77-23-6
1-Phenylcyclopentanecarboxylic acid 2-(2-diethylaminoethoxy)ethyl ester; 2-(diethylaminoethoxy)ethyl 1-phenyl-1-cyclopentanecarboxylate; 2-(diethylaminoethoxy)ethyl 1-phenylcyclopentyl-1-carboxylate; 1-phenylcyclopentane-1-carboxylic acid diethylaminoethoxyethyl ester; pentoxyverine; pentoxiverin.
C20H31NO3; mol wt 333.47.
C 72.03%, H 9.37%, N 4.20%, O 14.39%.

Description and references

Prepn: H. G. Morren, GB 753779; idem, US 2842585 (1956, 1958 both to Union Chimique Belge). Antispasmodic activity: D. Wellens, Arzneim.-Forsch. 17, 495 (1967). Clinical effect on lung function: E. Krieger, ibid. 22, 389 (1972).

Chemical structure

Properties

bp0.01 165-170°.

Derivative

Citrate.

Nomenclature

CAS number: 23142-01-0
UCB-2543; Antees (Oriental); Calnathal; Carbetane (Toyo Jozo); Cossym (Egnaro); Fustpentane; Germapect (Thiemann); Pencal (Tatsumi); Sedotussin (UCB); Toclase (Pfizer); Tosnone (Nippon Shoji); Tuclase (Pfizer).
C20H31NO3.C6H8O7; mol wt 525.59.
C 59.41%, H 7.48%, N 2.66%, O 30.44%.

Properties

Crystals, mp 93°. Freely sol in water, chloroform; sol in alcohol, acetone, ethyl acetate. Practically insol in ether, petr ether, benzene.

Therapeutic Category

Antitussive.

Keywords

Antitussive