1825. Carbostyril

Nomenclature

CAS number: 59-31-4
2(1H)-Quinolinone; 2-hydroxyquinoline; 2-quinolinol; 2(1H)-quinolone; o-aminocinnamic acid lactam.
C9H7NO; mol wt 145.16.
C 74.47%, H 4.86%, N 9.65%, O 11.02%.

Description and references

Prepn from quinoline by heating with potassium hydroxide to 225° under anhydr conditions: Tschitschibabin, Ber. 56, 1883 (1923); DE 406208; Chem. Zentralbl. 1925, I, 1536; Frdl. 14, 515.

Chemical structure

Properties

Prisms from methanol, mp 199-200°. Sublimes at atmospheric pressure without dec. A monohydrate has been obtained from a satd aq soln. pKb (18°) 8.71. Very sparingly sol in water: One gram dissolves in 950 ml H2O at 22°. Sol in alcohol, ether, dil HCl. Forms easily hydrolyzed Na and K salts.

Derivative

Compd with 1,3,5-trinitrobenzene.
(C9H7NO)2.C6H3N3O6; mol wt 503.42.
C 57.26%, H 3.40%, N 13.91%, O 25.43%.

Properties

Yellow needles, mp 178°.