1841. Cariporide

Nomenclature

CAS number: 159138-80-4
N-(Aminoiminomethyl)-4-(1-methylethyl)-3-(methylsulfonyl)benzamide; 4-isopropyl-3-(methanesulfonylbenzoyl)guanidine.
C12H17N3O3S; mol wt 283.35.
C 50.87%, H 6.05%, N 14.83%, O 16.94%, S 11.32%.

Description and references

Selective inhibitor of the sodium-hydrogen exchanger subtype 1 (NHE-1); protects against myocardial injury following ischemia and reperfusion. Prepn: H. J. Lang et al., EP 589336; eidem, US 5591754 (1994, 1997 both to Hoechst); A. Weichert et al., Arzneim.-Forsch. 47, 1204 (1997). Pharmacology: W. Scholz et al., Cardiovasc. Res. 29, 260 (1995). Symposium on pharmacology and clinical experience: Am. J. Cardiol. 83, Suppl. 10A, 1G-25G (1999). Review: W. Scholz et al., J. Thromb. Thrombolysis 8, 61-70 (1999).

Chemical structure

Properties

Colorless solid, mp 90-94° (dec).

Derivative

Methanesulfonate.

Nomenclature

CAS number: 159138-81-5
Cariporide mesylate; HOE-642.
C12H17N3O3S.CH3SO3H; mol wt 379.45.
C 41.15%, H 5.58%, N 11.07%, O 25.30%, S 16.90%.

Properties

Colorless needles from isopropanol + water, mp 227-230°.

Therapeutic Category

Cardioprotective.

Keywords

Cardioprotective