1842. Carisoprodol

Nomenclature

CAS number: 78-44-4
(1-Methylethyl)carbamic acid 2-[[(aminocarbonyl)oxy]methyl]-2-methylpentyl ester; N-isopropyl-2-methyl-2-propyl-1,3-propanediol dicarbamate; isopropyl meprobamate; isobamate; carisoprodate; Carisoma (Pharmax); Flexartal (Sanofi Winthrop); Rela (Schering); Sanoma (Heilit); Soma (Wallace Labs.); Somadril (Dumex); Somalgit (Inibsa).
C12H24N2O4; mol wt 260.33.
C 55.36%, H 9.29%, N 10.76%, O 24.58%.

Description and references

Prepn: Berger, Ludwig, US 2937119 (1960 to Carter Prod.). Pharmacology: Berger et al., J. Pharmacol. Exp. Ther. 127, 66 (1959).

Chemical structure

Properties

Crystals, mp 92-93°. Slightly bitter taste. Very sparingly sol in water: 30 mg/100 ml at 25°; 140 mg/100 ml at 50°. Sol in many common organic solvents. Practically insol in vegetable oils. Stable in dil acids and alkalies. LD50 in mice, rats (mg/kg): 2340, 1320 orally; 980, 450 i.p. (Berger).

Therapeutic Category

Muscle relaxant (skeletal).

Keywords

Muscle Relaxant (Skeletal)