1977. Cephalonic Acid
Nomenclature
CAS number: 18456-04-7
8-Hydroxy-5-oxoophiobola-3,6,19-trien-25-oic acid; ophiobolin D. C25H36O4; mol wt 400.55.
C 74.96%, H 9.06%, O 15.98%.
Description and references
Minor antibiotic metabolite produced by Cephalosporium caerulens. Exhibits weak activity against Staphylococcus aureus. Isolation, structure elucidation and physical data: Itai et al., Tetrahedron Lett. 1967, 4111; Nozoe et al., ibid. 4113. Crystal structure: Itai et al., Acta Crystallogr. 25B, 872 (1969). Synthetic studies on related compounds: P. C. Dutta, T. K. Das, Synth. Commun. 6, 253 (1976); W. G. Dauben, D. S. Hart, J. Org. Chem. 42, 922 (1977); R. K. Boeckman et al., ibid. 3630.
