1978. Cephalonium

Nomenclature

CAS number: 5575-21-3
4-(Aminocarbonyl)-1-[[(6R,7R)-2-carboxy-8-oxo-7-[[2-(2-thienyl)acetyl]amino]-5-thia-1-azabicyclo[4.2.0]oct-2-en-3-yl]methyl]pyridinium inner salt; cefalonium; 2-thienylmethyl isonicotinamide cephalosporin CA; Cepravin Dry Cow (Schering-Plough).
C20H18N4O5S2; mol wt 458.51.
C 52.39%, H 3.96%, N 12.22%, O 17.45%, S 13.99%.

Description and references

Cephalosporin antibiotic. Prepn: E. H. Flynn, GB 1067644 (1967 to Lilly); and antibacterial activity: J. L. Spencer et al., Antimicrob. Agents Chemother. 1966, 573. Determn in milk samples: J. E. Hillerton et al., J. Dairy Sci. 82, 704 (1999). Prophylactic use in dry udder infections: R. Curtis et al., Vet. Rec. 100, 557 (1977); in mastitis: J. H. Williamson et al., N. Z. Vet. J. 43, 228 (1995); in combination with a teat sealer: M. W. Woolford et al., ibid. 46, 12 (1998).

Chemical structure

Properties

Crystals from hot water, mp 147-150° (dec). uv max: 233, 262 nm (ε 16650, 13550). pKa: 3.3.

Therapeutic Category (Veterinary)

Prophylactic use in mastitis and dry udder therapy.