Description and references

Cholecystokinin analog; decapeptide discovered in the skins of Australian amphibians: V. Erspamer et al., Nature 212, 204 (1966). Isoln from Hyla caerulea and structure: A. Anastasi et al., Experientia 23, 699 (1967); eidem, Arch. Biochem. Biophys. 125, 57 (1968). Synthesis: L. Bernardi et al., Experientia 23, 700 (1967); eidem, ZA 6704716; eidem, US 3472832 (1968, 1969 to Soc. Farm. Italia). Shows hypotensive activity, stimulates smooth muscle and increases gastric, pancreatic, and biliary secretions: V. Erspamer et al., Experientia 23, 702 (1967). Series of articles on metabolism: Eur. J. Biochem. 91, 21-48 (1978). Pharmacodynamics: N. Iwatsuki, O. H. Petersen, J. Cell Biol. 79, 533 (1978); T. Fujita et al., Adv. Exp. Med. Biol. 106, 147 (1978). Diagnostic use: R. Fujita et al., Acta Gastroenterol. Belg. 40, 167 (1977); C. Monti et al., Radiology 129, 611 (1978). Toxicology: T. Chieli et al., Toxicol. Appl. Pharmacol. 23, 480 (1972). Reviews of pharmacology and clinical applications: G. Bertaccini, Pharmacol. Rev. 28, 127 (1976); and toxicology: M. E. Vincent et al., Pharmacotherapy 2, 223 (1982).

Properties

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