2018. Cetamolol

Nomenclature

CAS number: 34919-98-7
2-[2-[3-[(1,1-Dimethylethyl)amino]-2-hydroxypropoxy]phenoxy]-N-methylacetamide; 2-[o-[3-(t-butylamino)-2-hydroxypropoxy]phenoxy]-N-methylacetamide; (±)-1-t-butylamino-3-(o-N-methylcarbamoylmethoxyphenoxy)propan-2-ol.
C16H26N2O4; mol wt 310.39.
C 61.91%, H 8.44%, N 9.03%, O 20.62%.

Description and references

Cardioselective β1-adrenergic blocker. Prepn: BE 767781; D. J. Lecount, C. J. Squire, US 4059622 (1971, 1977 both to ICI). Cardiovascular effects in dogs: G. Beaulieu et al., Can. J. Physiol. Pharmacol. 63, 610 (1984). Determn in human serum: M. D. Stern, Clin. Biochem. 17, 162 (1984). Pharmacology and pharmacodynamics in humans: M. A. Klausner et al., Curr. Ther. Res. 36, 379 (1984); J. Coelho et al., Br. J. Clin. Pharmacol. 19, 411 (1985). Evaluation in hypertensive patients: W. B. White et al., Clin. Pharmacol. Ther. 39, 664 (1986).

Chemical structure

Properties

Crystals from benzene-petr ether, mp 96-97°.

Derivative

Hydrochloride.

Nomenclature

CAS number: 77590-95-5
AI-27303; ICI-72222; Betacor (Ayerst).
C16H26N2O4.HCl; mol wt 346.85.
C 55.40%, H 7.85%, N 8.08%, O 18.45%, Cl 10.22%.

Therapeutic Category

Antihypertensive.

Keywords

β-Adrenergic Blocker; Antihypertensive; Aryloxypropanolamine Derivatives