2021. Cetiedil

Nomenclature

CAS number: 14176-10-4
α-Cyclohexyl-3-thiopheneacetic acid 2-(hexahydro-1H-azepin-1-yl)ethyl ester; α-cyclohexyl-α-(3-thienyl)acetic acid 2-hexamethyleneiminoethyl ester.
C20H31NO2S; mol wt 349.53.
C 68.72%, H 8.94%, N 4.01%, O 9.15%, S 9.17%.

Description and references

Prepn: Pons, Robba, FR 1460571 and Pons et al., FR M5504 (1966, 1967, both to Innothera), C.A. 68, 59429d (1968); 71, 91286c (1969). Prepn and activity: Robba, LeGuen, Chim. Ther. 2, 120 (1967). Antisickling effect: T. Asakura et al., Proc. Natl. Acad. Sci. USA 77, 2955 (1980); L. R. Berkowitz, E. P. Orringer, J. Clin. Invest. 68, 1215 (1981).

Chemical structure

Derivative

Citrate.

Nomenclature

CAS number: 16286-69-4
Stratene (Innothera; Sigma-Tau); Vasocet (Winthrop).
C20H31NO2S.C6H8O7; mol wt 541.65.
C 57.65%, H 7.26%, N 2.59%, O 26.58%, S 5.92%.

Properties

Crystals from ethanol-ether, mp 115°.

Derivative

Hydrochloride.
C20H31NO2S.HCl; mol wt 385.99.
C 62.23%, H 8.36%, N 3.63%, O 8.29%, S 8.31%, Cl 9.18%.

Properties

Crystals from acetonitrile, mp 152° (Robba, LeGuen); also mp 143° (Pons, Robba).

Therapeutic Category

Vasodilator (peripheral).

Keywords

Vasodilator (Peripheral)