2025. Cetrimonium Bromide
Nomenclature
CAS number: 57-09-0
N,N,N-Trimethyl-1-hexadecanaminium bromide (1:1); hexadecyltrimethylammonium bromide; cetyltrimethylammonium bromide; Bromat; Cetab; Cetavlon (Ayerst); Cetylamine; C.T.A.B.; Lissolamine V; Micol; Quamonium. C19H42BrN; mol wt 364.45.
C 62.62%, H 11.62%, Br 21.92%, N 3.84%.
Description and references
Prepd from cetyl bromide and trimethylamine: Shelton et al., J. Am. Chem. Soc. 68, 753 (1946). Toxicity and pharmacology: B. Isomaa, K. Bjondahl, Acta Pharmacol. Toxicol. 47, 17 (1980). RP-HPLC determn in commercial formulations: A. Malenovic et al., Farmaco 60, 157 (2005).
Properties
Crystals, mp 237-243°. Soluble in about 10 parts water. Freely sol in alc; sparingly sol in acetone. Practically insol in ether, benzene. Stable in acid soln. LD50 in mice, rats (mg/kg): 32.0, 44.0 i.v. (Isomaa, Bjondahl).Derivative
p-Toluenesulfonate analog.Nomenclature
CAS number: 138-32-9
Cetrimonium tosylate; Cetats (Zeeland). C26H49NO3S; mol wt 455.74.
C 68.52%, H 10.84%, N 3.07%, O 10.53%, S 7.04%.
Note
Cetrimide is a mixture consisting chiefly of tetradecyltrimethylammonium bromide together with smaller amounts of dodecyltrimethylammonium bromide and cetrimonium bromide.Use
As cationic detergent and antiseptic; as laboratory reagent.Therapeutic Category
Antiseptic, disinfectant.
Therapeutic Category (Veterinary)
Antiseptic, cleansing agent.Keywords
Antiseptic/Disinfectant; Quaternary Ammonium Compounds