2026. Cetrorelix

Nomenclature

CAS number: 120287-85-6
N-Acetyl-3-(2-naphthalenyl)-d-alanyl-4-chloro-d-phenylalanyl-3-(3-pyridinyl)-d-alanyl-l-seryl-l-tyrosyl-N5-(aminocarbonyl)-d-ornithyl-l-leucyl-l-arginyl-l-prolyl-d-alaninamide; Ac-d-Nal(2)1-d-Phe(4Cl)2-d-Pal(3)3-d-Cit6-d-Ala10-LH-RH; SB-75.
C70H92ClN17O14; mol wt 1431.04.
C 58.75%, H 6.48%, Cl 2.48%, N 16.64%, O 15.65%.

Description and references

Decapeptide LH-RH antagonist. Prepn: A. V. Schally, S. Bajusz, EP 299402 (1989 to Asta); eidem, US 4800191 (1989); S. Bajusz et al., Int. J. Pept. Protein Res. 32, 425 (1988). Structural study: A. Müller et al., ibid. 43, 264 (1994). HPLC determn in plasma: H. H. Raffel et al., J. Chromatogr. B 653, 102 (1994). Pharmacology: T. Reissmann et al., Eur. J. Cancer 32A, 1574 (1996). Clinical evaluation in prostatic cancer: D. Gonzalez-Barcena et al., Urology 45, 275 (1995); in assisted fertilization: C. Albano et al., Fertil. Steril. 67, 917 (1997). Review of development and clinical experience in female infertility and endometriosis: D. Finas et al., Expert Opin. Pharmacother. 7, 2155-2168 (2006).

Chemical structure

Derivative

Acetate.

Nomenclature

CAS number: 145672-81-7
D-20761; Cetrotide (Serono).

Properties

Sol in water.

Therapeutic Category

Antineoplastic (hormonal). In treatment of infertility.

Keywords

Antineoplastic (Hormonal); LH-RH Analogs; LH-RH Antagonist