2070. Chloral Formamide

Nomenclature

CAS number: 515-82-2
N-(2,2,2-Trichloro-1-hydroxyethyl)formamide; chloralamide; chloramide.
C3H4Cl3NO2; mol wt 192.43.
C 18.72%, H 2.10%, Cl 55.27%, N 7.28%, O 16.63%.

Description and references

Prepn or manuf from chloral and formamide: Bennett, Campbell, Q. J. Pharm. Pharmacol. 8, 398 (1955); and herbicidal activity: Reuter, Sehring, DE 1168161 (1964 to Boehringer, Ing.), C.A. 62, 1024g (1965).

Chemical structure

Properties

Crystals from water of 30% alc, mp 124-126°, also reported as 115-116° (Bennett, Campbell). Soluble in water; readily sol in alcohol, ether, glycerol, acetone, ethyl acetate. Dec by hot solvents.

Therapeutic Category

Sedative, hypnotic.

Keywords

Sedative/Hypnotic; Chloral Derivatives