2076. Chloraminophenamide

Nomenclature

CAS number: 121-30-2
4-Amino-6-chloro-1,3-benzenedisulfonamide; 4-amino-6-chloro-m-benzenedisulfonamide; 5-chloro-2,4-bis(sulfonamido)aniline; 6-amino-4-chlorobenzene-1,3-disulfonamide; 5-chloro-2,4-disulfamylaniline; Idorese.
C6H8ClN3O4S2; mol wt 285.73.
C 25.22%, H 2.82%, Cl 12.41%, N 14.71%, O 22.40%, S 22.44%.

Description and references

Prepn: Novello, Sprague, J. Am. Chem. Soc. 79, 2028 (1957); Novello, US 2809194; US 2965655; US 2965656 (1957, 1960, 1960 all to Merck & Co.); Novello et al., J. Org. Chem. 25, 965 (1960).

Chemical structure

Properties

Crystals from aq ethanol, mp 251-252°. uv max (ethanol): 223.5-224.5, 265-266, 312-314 nm (ε 41776, 18633, 3874). Slightly sol in water; more freely sol in alkalies.

Therapeutic Category

Diuretic.

Keywords

Diuretic; Sulfonamide Derivatives