2075. Chloramine-T

Nomenclature

CAS number: 127-65-1
N-Chloro-4-methylbenzenesulfonamide sodium salt (1:1); (N-chloro-p-toluenesulfonamido)sodium; sodium p-toluenesulfonchloramide; chloramine; tosylchloramide sodium; Chlorazene (WPC); Euclorina (Bracco); Halamid (Akzo).
C7H7ClNNaO2S; mol wt 227.64.
C 36.93%, H 3.10%, Cl 15.57%, N 6.15%, Na 10.10%, O 14.06%, S 14.09%.

Description and references

Prepd via p-toluenesulfonamide: Chattaway, J. Chem. Soc. 87, 145 (1905); Inglis, J. Soc. Chem. Ind. London 37, 288 (1918); F. J. Welcher, Organic Analytical Reagents vol. 4 (Van Nostrand, New York, 1948) pp 316-320. Reviews of synthetic applications: M. M. Campbell, G Johnson, Chem. Rev. 78, 65-79 (1978); G. Agnihotri, Synlett 2005, 2857-2858.

Chemical structure

Derivative

Trihydrate.

Nomenclature

CAS number: 7080-50-4
C7H7ClNNaO2S.3H2O; mol wt 281.69.
C 29.85%, H 4.65%, Cl 12.59%, N 4.97%, Na 8.16%, O 28.40%, S 11.38%.

Properties

Prisms. Loses water on drying. Dec slowly on exposure to air. Keep well closed. Corrosive Fairly sol in water. Practically insol in benzene, chloroform, ether. Dec by alc.

Use

Detection of bromate and halogens. Source of halonium ions and nitrogen anions in organic synthesis.

Therapeutic Category

Antibacterial.

Therapeutic Category (Veterinary)

Antiseptic (topical).

Keywords

Antibacterial (Synthetic); Sulfonamides