2106. Chlormezanone

Nomenclature

CAS number: 80-77-3
2-(4-Chlorophenyl)tetrahydro-3-methyl-4H-1,3-thiazin-4-one 1,1-dioxide; 2-(p-chlorophenyl)perhydro-3-methyl-1,3-thiazin-4-one 1,1-dioxide; 2-(4-chlorophenyl)-3-methyl-4-metathiazanone 1,1-dioxide; dichloromethazanone; chlormethazanone; Alinam (Lucien); Banabin-Sintyal; Fenarol (Winthrop); Lobak; Mio-Sed; Rexan; Rilansyl; Rilaquil; Rilassol; Supotran (Winthrop); Suprotan; Tanafol; Trancopal (Winthrop); Trancote (Sawai); Transanate (Teikoku Zoki).
C11H12ClNO3S; mol wt 273.74.
C 48.26%, H 4.42%, Cl 12.95%, N 5.12%, O 17.53%, S 11.71%.

Description and references

Prepn starting with 4-chlorobenzylidenemethylamine: Surrey et al., J. Am. Chem. Soc. 80, 3469 (1958); GB 815203 (1959 to Sterling Drug).

Chemical structure

Properties

Crystals, mp 116.2-118.2°. Soly in water at 25° less than 0.25% (w/v); in 95% ethanol at 25° less than 1.0% (w/v).

Therapeutic Category

Anxiolytic; muscle relaxant (skeletal).

Keywords

Anxiolytic; Muscle Relaxant (Skeletal)