2111. Chloroacetanilide

C8H8ClNO; mol wt 169.61.
C 56.65%, H 4.75%, Cl 20.90%, N 8.26%, O 9.43%.

Description and references

Prepn of m-, o- and p-isomers: Roberts et al., J. Org. Chem. 24, 654 (1959). Sepn of o- and p-isomers: Orton, Bradford, J. Chem. Soc. 1927, 986.

Chemical structure

Derivative

m-Chloroacetanilide.

Nomenclature

N-(3-Chlorophenyl)acetamide; 3′-chloroacetanilide.

Properties

Needles from 50% glacial acetic acid, mp 77-78°. Readily sol in alcohol, benzene, carbon disulfide; very slightly sol in ligroin. uv max (95% ethanol): 245 nm (log ε 4.19).

Derivative

o-Chloroacetanilide.

Properties

Needles from dil glacial acetic acid, mp 87-88°. Sublimes at about 50-60°. Practically insol in water, alkalies; sol in alc; more sol in benzene than corresponding p-isomer. uv max (95% ethanol): 240 nm (log ε 4.02).

Derivative

p-Chloroacetanilide.

Properties

Orthorhombic crystals from aq glacial acetic acid, alc, or acetone. mp 178-179°. d422 1.385. Practically insol in water; readily sol in alc, ether, carbon disulfide; slightly sol in CCl4, benzene. uv max (95% ethanol): 249 nm (log ε 4.25).