Nomenclature
CAS number: 124-48-1
Dibromochloromethane; chlorobromoform; monochlorodibromomethane; DBCM; NCI-C55254.
CHBr
2Cl; mol wt 208.28.
C 5.77%, H 0.48%, Br 76.73%, Cl 17.02%.
Description and references
Trihalomethane contaminant found in chlorinated
water. Prepn: O. Jacobsen, R. Neumeister, Ber. 15, 599 (1882); M. Fedorynski et
al., Synth. Commun. 7, 287 (1977). Toxicity studies: F. J. Bowman et al., Toxicol. Appl. Pharmacol. 44, 213 (1978); Y. Aida et al., J. Toxicol. Sci. 17, 119 (1992). Review of
toxicology and human exposure: Toxicological
Profile for Bromoform and Dibromochloromethane (PB2006-100001,
2005) 273 pp. Review of carcinogenic risk: IARC Monographs 52, 243-268 (1991).
Properties
Liquid. bp 121.3-121.8° (Fedorynski); also reported as bp 123-125° (Jacobsen). d15 2.4450. nD20 1.5471. Sol in ethanol, ether, acetone. LD50 in male, female rats (mg/kg): 370, 760 orally (Aida); in male, female mice (mg/kg): 800, 1200 by gavage (Bowman).Use
Chemical reagent/intermediate in organic synthesis.