2145. α-Chlorohydrin

Nomenclature

CAS number: 96-24-2
3-Chloro-1,2-propanediol; 3-chloro-1,2-dihydroxypropane; α-monochlorohydrin; β,β′-dihydroxyisopropyl chloride; glycerol α-monochlorohydrin; 3-chloropropylene glycol; Epibloc (Pestcon).
C3H7ClO2; mol wt 110.54.
C 32.60%, H 6.38%, Cl 32.07%, O 28.95%.

Description and references

Prepd from glycerol and HCl gas: Conant, Quayle, Org. Synth. coll. vol. I, 294 (1941). Toxicity study: C. H. Hine et al., Arch. Ind. Health 14, 250 (1956).

Chemical structure

Properties

Liquid. Sweetish taste. Tendency to turn straw color. d420 1.3218. nD20 1.4831. bp760 213° (dec); bp14 114-120°; bp11 115-117°. Sol in water, alcohol, ether. LD50 in mice, rats (g/kg): 0.16, 0.15 orally (Hine).

Use

To lower the freezing point of dynamite; in the manuf of dye intermediates. As rodent chemosterilant.