2157. Chloroprednisone

Nomenclature

CAS number: 52080-57-6
(6α)-Chloro-17,21-dihydroxypregna-1,4-diene-3,11,20-trione; 6α-chloro-1,4-pregnadiene-17α,21-diol-3,11,20-trione.
C21H25ClO5; mol wt 392.87.
C 64.20%, H 6.41%, Cl 9.02%, O 20.36%.

Description and references

Prepn: Batres et al., DE 1079042 (1960 to Syntex). Prepn of the 21-acetate by selenium dioxide dehydrogenation of 6α-chlorocortisone 21-acetate: Ringold et al., J. Am. Chem. Soc. 80, 6464 (1958); Ringold, Rosenkranz, US 2957895 (1960 to Syntex).

Chemical structure

Derivative

21-Acetate.

Nomenclature

CAS number: 14066-79-6
Topilan (Syntex).
C23H27ClO6; mol wt 434.91.
C 63.52%, H 6.26%, Cl 8.15%, O 22.07%.

Properties

Crystals from acetone + hexane, mp 217-219°. uv max (ethanol): 237 nm (log ε 4.19). [α]D +144° (chloroform).

Therapeutic Category

Glucocorticoid (topical).

Keywords

Glucocorticoid