2161. 6-Chloropurine

Nomenclature

CAS number: 87-42-3
C5H3ClN4; mol wt 154.56.
C 38.85%, H 1.96%, Cl 22.94%, N 36.25%.

Description and references

Prepd by the action of phosphorus oxychloride on hypoxanthine in N,N-dimethylaniline: Bendich et al., J. Am. Chem. Soc. 76, 6073 (1954). Antineoplastic activity in vivo: A. C. Sartorelli, B. A. Booth, Experientia 21, 457 (1965).

Chemical structure

Properties

Blunt needles from water, dec 175-177° (hot stage preheated to 170°). Also reported as not melted at 290°. uv max (pH 5.2): 265 nm (ε 9120); (pH 13): 274 nm (ε 8790). Soly in water: 0.5% at 20°, also reported as 1 g/182 ml at 24°. Sol in ether, dimethylformamide.