2162. Chloropyramine

Nomenclature

CAS number: 59-32-5
N-[(4-Chlorophenyl)methyl]-N′,N′-dimethyl-N-2-pyridinyl-1,2-ethanediamine; 2-[(p-chlorobenzyl)[2-(dimethylamino)ethyl]amino]pyridine; N-dimethylaminoethyl-N-p-chlorobenzyl-α-aminopyridine; N,N-dimethyl-N′-(p-chlorobenzyl)-N′-(2-pyridyl)ethylenediamine; halopyramine.
C16H20ClN3; mol wt 289.80.
C 66.31%, H 6.96%, Cl 12.23%, N 14.50%.

Description and references

Prepn: Phillips, Cates, US 2607778 (1952 to Merck & Co.); Howard, US 2569314 (1951 to Am. Cyanamid); CH 264754; CH 266234; CH 266235 (1950); GB 651596 (1951) (all to Geigy).

Chemical structure

Properties

Light yellow, viscous, oily liquid. Pungent odor. bp0.2 154-155°.

Derivative

Hydrochloride.

Nomenclature

CAS number: 6170-42-9
Synopen (Novartis); Synpen (Novartis).
C16H20ClN3.HCl; mol wt 326.26.
C 58.90%, H 6.49%, Cl 21.73%, N 12.88%.

Properties

Crystals from acetone, mp 172-174°.

Therapeutic Category

Antihistaminic.

Keywords

Antihistaminic; Ethylenediamine Derivatives