2178. Chlorphenesin

Nomenclature

CAS number: 104-29-0
3-(4-Chlorophenoxy)-1,2-propanediol; p-chlorophenyl α-glyceryl ether; Adermykon; Mycil (BDH).
C9H11ClO3; mol wt 202.63.
C 53.35%, H 5.47%, Cl 17.50%, O 23.69%.

Description and references

Prepd by condensing equimol amts of p-chlorophenol and glycidol in the presence of a tertiary amine or a quaternary ammonium salt as catalyst: Bradley, Forrest, GB 628497 (1949 to British Drug Houses).

Chemical structure

Properties

Crystals, mp 77-79°. Soly in water is less than 1%, may be increased by the addition of solubilizers such as ethylurea or propylene glycol: Berger et al., US 2468423 (1949 to British Drug Houses).

Therapeutic Category

Antifungal (topical).

Keywords

Antifungal (Synthetic)