2179. Chlorphenesin Carbamate

Nomenclature

CAS number: 886-74-8
3-(4-Chlorophenoxy)-1,2-propanediol-1-carbamate; carbamic acid 3-(p-chlorophenoxy)-2-hydroxypropyl ester; 3-(p-chlorophenoxy)-2-hydroxypropyl carbamate; 1,2-propanediol-3-(p-chlorophenoxy)-1-carbamate; Maolate (Upjohn); Rinlaxer (Taisho).
C10H12ClNO4; mol wt 245.66.
C 48.89%, H 4.92%, Cl 14.43%, N 5.70%, O 26.05%.

Description and references

Prepn: Collins, Matthews, US 3161567; Parker, US 3214336 (1964, 1965 both to Upjohn). Clinical evaluation of analgesic activity: L. J. Cass, W. S. Frederick, J. New Drugs 2, 366 (1962).

Chemical structure

Properties

Crystals from benzene + toluene, mp 89-91°. Readily sol in 95% ethanol, acetone, ethyl acetate; fairly readily sol in dioxane. Almost insol in cold water, benzene, cyclohexane. LD50 orally in rats: 748 mg/kg; i.v. in mice: 239 mg/kg (Cass, Frederick).

Therapeutic Category

Muscle relaxant (skeletal).

Therapeutic Category (Veterinary)

Muscle relaxant (skeletal).

Keywords

Muscle Relaxant (Skeletal)