2182. Chlorphentermine

Nomenclature

CAS number: 461-78-9
4-Chloro-α,α-dimethylbenzeneethanamine; 4-chloro-α,α-dimethylphenethylamine; α,α-dimethyl-p-chlorophenethylamine; 1-(p-chlorophenyl)-2-methyl-2-propylamine; 1-(p-chlorophenyl)-2-methyl-2-aminopropane; clorfentermina; Lucofen (Lundbeck); Teramine (Darby).
C10H14ClN; mol wt 183.68.
C 65.39%, H 7.68%, Cl 19.30%, N 7.63%.

Description and references

Prepn: Bachman et al., J. Am. Chem. Soc. 76, 3972 (1954); Ferrari, Farmaco Ed. Sci. 15, 337 (1960); FR M1299 and FR 1296132 (1962 to Simes), C.A. 58, 4467e, 3352g (1963); GB 90633l (1962 to Kefalas), C.A. 58, 6654c (1963). Pharmacology: Jun et al., Can. J. Pharm. Sci. 4, 27 (1969); Ciborska et al., Acta Pol. Pharm. 26, 595 (1969); Moeller-Nielsen, Dubnick, Proc. Int. Symp. Amphetamines Relat. Compounds 1969, E. Costa, Ed. (Raven Press, New York, 1970) pp 63-73.

Chemical structure

Properties

Liquid. bp2 100-102°.

Derivative

Hydrochloride.

Nomenclature

CAS number: 151-06-4
Pre-Sate (Warner-Lambert).
C10H14ClN.HCl; mol wt 220.14.
C 54.56%, H 6.87%, Cl 32.21%, N 6.36%.

Properties

Crystals from alcohol + ether, mp 234°. Soly in water: >20%. pH of 1% aq soln ≈5.5. LD50 in mice (mg/kg): 270 orally; 267 s.c. (Ciborska).

Note

This is a controlled substance (stimulant): 21 CFR, 1308.13.

Therapeutic Category

Anorexic.

Keywords

Anorexic; CNS Stimulant