2263. Ciclesonide

Nomenclature

CAS number: 126544-47-6
(11β,16α)-16,17-[[(R)-Cyclohexylmethylene]bis(oxy)]-11-hydroxy-21-(2-methyl-1-oxopropoxy)pregna-1,4-diene-3,20-dione; BY-9010; Alvesco (Altana); Osonide (Ranbaxy).
C32H44O7; mol wt 540.69.
C 71.08%, H 8.20%, O 20.71%.

Description and references

Inhaled corticosteroid prodrug; de-esterified in the lung to the active metabolite, desisobutyryl-ciclesonide. Prepn: J. Calatayud et al., DE 4129535; eidem, US 5482934 (1992, 1996 both to Elmu). Clinical pharmacokinetics and pharmacodynamics: H. Derendorf, J. Clin. Pharmacol. 47, 782 (2007). Review of pharmacology and clinical experience in asthma: G. L. Colice, Expert Opin. Pharmacother. 7, 2107-2117 (2006). Clinical trial in pediatric asthma: E. W. Gelfand et al., J. Pediatr. 148, 377 (2006); in allergic rhinitis: P. Chervinsky et al., Ann. Allergy Asthma Immunol. 99, 69 (2007).

Chemical structure

Therapeutic Category

Anti-asthmatic; glucocorticoid.

Keywords

Glucocorticoid; Antiasthmatic (Steroidal, Inhalant)