2269. Cifenline

Nomenclature

CAS number: 53267-01-9
2-(2,2-Diphenylcyclopropyl)-4,5-dihydro-1H-imidazole; (±)-2-(2,2-diphenylcyclopropyl)-2-imidazoline; 1-(2-Δ2-imidazolinyl)-2,2-diphenylcyclopropane; cibenzoline; Ro-22-7796; UP-33-901.
C18H18N2; mol wt 262.35.
C 82.41%, H 6.92%, N 10.68%.

Description and references

Prepn: BE 807630; J. C. Cognaco, US 3903104 (1974, 1975 both to Hexachemie). Activity and tolerance: D. Herpin et al., Acta Cardiol. 36, 131 (1981). Electrophysiological effects in man: J. F. Thizy et al., Lyon Med. 245, 119 (1981). Clinical trial: D. Herpin et al., Curr. Ther. Res. 30, 742 (1981).

Chemical structure

Properties

Crystals from petr ether, mp 103-104°. LD100 in rats (mg/kg): 64 i.v. (Cognaco).

Derivative

Succinate.

Nomenclature

CAS number: 100678-32-8
Cibenol (Fujisawa); Cipralan (Roche); Exacor (Searle).
C18H18N2.C4H6O4; mol wt 380.44.
C 69.46%, H 6.36%, N 7.36%, O 16.82%.

Properties

Crystals from ethanol + ether, mp 165°.

Therapeutic Category

Antiarrhythmic.

Keywords

Antiarrhythmic