2282. Cinacalcet

Nomenclature

CAS number: 226256-56-0
(αR)-α-Methyl-N-[3-[3-(trifluoromethyl)phenyl]propyl]-1-napthalenemethanamine; (R)-N-(3-(3-(trifluoromethyl)phenyl)propyl)-1-(1-napthyl)ethylamine; AMG-073; KRN-1493.
C22H22F3N; mol wt 357.41.
C 73.93%, H 6.20%, F 15.95%, N 3.92%.

Description and references

Calcimimetic. Prepn: B. C. Van Wagenen et al., US 6211244 (2001 to NPS Pharmaceuticals). Review of pharmacology and mechanism of action: M. Wada, N. Nagano, Nephrol. Dial. Transplant. 18, Suppl. 3, iii13-iii17 (2003); of clinical development: N. Franceschini et al., Expert Opin. Invest. Drugs 12, 1413-1421 (2003). Clinical trial in secondary hyperparathyroidism: G. A. Block et al., N. Engl. J. Med. 350, 1516 (2004).

Chemical structure

Derivative

Hydrochloride.

Nomenclature

CAS number: 364782-34-3
Mimpara (Amgen); Sensipar (Amgen).
C22H22F3N.HCl; mol wt 393.87.
C 67.09%, H 5.89%, F 14.47%, N 3.56%, Cl 9.00%.

Properties

White to off-white, crystalline solid. Sol in methanol, 95% ethanol; slightly sol in water.

Therapeutic Category

Antihyperparathyroid.

Keywords

Antihyperparathyroid