2291. Cinepazide

Nomenclature

CAS number: 23887-46-9
1-[2-Oxo-2-(1-pyrrolidinyl)ethyl]-4-[1-oxo-3-(3,4,5-trimethoxyphenyl)-2-propenyl]piperazine; 1-[(1-pyrrolidinylcarbonyl)methyl]-4-(3,4,5-trimethoxycinnamoyl)piperazine; 1-[4-[2-oxo-2-(1-pyrrolidinyl)ethyl]-1-piperazinyl]-3-(3,4,5-trimethoxyphenyl)-2-propen-1-one; 1-[4-[(3′,4′,5′-trimethoxycinnamoyl)-1-piperazinyl]acetyl]pyrrolidine.
C22H31N3O5; mol wt 417.50.
C 63.29%, H 7.48%, N 10.06%, O 19.16%.

Description and references

Prepn: BE 730345; C. P. Fauran et al., US 3634411 (1969, 1972 both to Delalande); C. P. Fauran, M. J. Turin, Chim. Ther. 4, 290 (1969). Pharmacology: G. Huguet et al., ibid. 293; E. Marmo et al., Farmaco Ed. Prat. 28, 132 (1973); B. M. Pourrias et al., Therapie 29, 29, 43 (1974).

Chemical structure

Derivative

Maleate.

Nomenclature

CAS number: 26328-04-1
MD-67350; Brendil (Daiichi); Vasodistal (Delalande).
C22H31N3O5.C4H4O4; mol wt 533.57.
C 58.53%, H 6.61%, N 7.88%, O 26.99%.

Properties

Crystals from abs ethanol, mp 135°. LD50 in mice, rats (mg/kg): 1000, 1310 orally; 617, 414 i.v. (Pourrias).

Therapeutic Category

Vasodilator (peripheral).

Keywords

Vasodilator (Peripheral)