2307. Cinobufotalin

Nomenclature

CAS number: 1108-68-5
(3β,5β,15β,16β)-16-(Acetyloxy)-14,15-epoxy-3,5-dihydroxybufa-20,22-dienolide; 14,15β-epoxy-3β,5,16β-trihydroxy-5β-bufa-20,22-dienolide 16-acetate.
C26H34O7; mol wt 458.54.
C 68.10%, H 7.47%, O 24.42%.

Description and references

Isolated from the Chinese drug Ch'an Su which is prepd from Chinese toads (Bufo asiaticus = bufo gargarizans Cantor). Isoln: Kotake, Kuwada, C.A. 31, 70652 (1937); Ruckstubl, Meyer, Helv. Chim. Acta 40, 1270 (1957). Structure: Bernoulli et al., ibid. 45, 240 (1962).

Chemical structure

Properties

Octahedrons from acetone, mp 259-262°. [α]D20 +11°. uv max: 295 nm (log ε 3.72).