2308. Cinolazepam

Nomenclature

CAS number: 75696-02-5
7-Chloro-5-(2-fluorophenyl)-2,3-dihydro-3-hydroxy-2-oxo-1H-1,4-benzodiazepine-1-propanenitrile; 1-(2-cyanoethyl)-7-chloro-3-hydroxy-5-(2′-fluorophenyl)-1,3-dihydro-2H-1,4-benzodiazepin-2-one; OX-373; Gerodorm (Gerot).
C18H13ClFN3O2; mol wt 357.77.
C 60.43%, H 3.66%, Cl 9.91%, F 5.31%, N 11.75%, O 8.94%.

Description and references

Prepn: L. H. Schlager, DE 2950235; idem, US 4388313 (1980, 1983 both to Gerot). Benzodiazepine receptor affinity: W. Sieghart, A. Schuster, Biochem. Pharmacol. 33, 4033 (1984). Polarographic and HPLC analyses: H. Oelschl"ager et al., Arch. Pharm. 325, 65 (1992). Clinical pharmacokinetics: J. Grünberger et al., Adv. Ther. 4, 84 (1987). Clinical evaluation in insomnia: B. Saletu et al., Int. J. Clin. Pharmacol. Res. 7, 407 (1987).

Chemical structure

Properties

Crystals from ethanol, mp 190-193°.

Therapeutic Category

Sedative, hypnotic.

Keywords

Sedative/Hypnotic; Benzodiazepine Derivatives