Description and references

Antinociceptive agent that inhibits release of calcitonin gene related peptide and substance P, q.v., from the spinal cord. Prepn: A. Colombo et al., EP 289380; eidem, US 5017596 (1988, 1991 both to Esteve). Prepn of isomers: J. A. Hueso-Rodriguez et al., Bioorg. Med. Chem. Lett. 3, 269 (1993). CE determn of chemical and enantiomeric purity: A. Gómez-Gomar et al., J. Chromatogr. A 950, 257 (2002). Pharmacology: I. Alvarez et al., Methods Find. Exp. Clin. Pharmacol. 22, 211 (2000). Mechanism of action study: S. Ballet et al., Neuropharmacology 40, 578 (2001). Clinical evaluation in chronic neuropathic pain: P. Shembalkar et al., Curr. Med. Res. Opin. 17, 262 (2001); in renal colic: I. Pavlik et al., Curr. Ther. 26, 1061 (2004). Review: N. Monck, Curr. Opin. Investig. Drugs 2, 1269-1272 (2001).

Derivative