13-02289. Ciclosidomine [Archived]

Nomenclature

CAS number: 66564-16-7
N-(Cyclohexylcarbonyl)-3-(4-morpholinyl)sydnone imine.
C13H20N4O3; mol wt 280.32.
C 55.70%, H 7.19%, N 19.99%, O 17.12%.

Description and references

Peripheral vasodilator similar to molsidomine. Prepn: FR 1551013; GB 1198283 (1968, 1970 both to Boehringer, Ing.). Clinical evaluation: J. Vos, E. J. D. Mees, Br. J. Clin. Pharmacol. 8, 155 (1979). Effect on blood pressure and heart rate: R. G. Shanks et al., ibid. 18, 232 (1984). Tissue distribution and excretion: M. R. Matteo et al., Arzneim.-Forsch. 35, 329 (1985).

Chemical structure

Derivative

Hydrochloride.

Nomenclature

CAS number: 26209-07-4
PR-G 138-Cl; Neopres (Boehringer, Ing.).
C13H20N4O3.HCl; mol wt 316.78.
C 49.29%, H 6.68%, N 17.69%, O 15.15%, Cl 11.19%.

Properties

Crystalline powder, mp 187°.

Therapeutic Category

Antihypertensive.

Keywords

Antihypertensive

Status

This monograph has been retired and is no longer subject to revision or update.