2338. Clanobutin

Nomenclature

CAS number: 30544-61-7
4-[(4-Chlorobenzoyl)(4-methoxyphenyl)amino]butanoic acid; 4-[p-chloro-N-(p-methoxyphenyl)benzamido]butyric acid; N-(p-chlorobenzoyl)-γ-(p-anisidino)butyric acid; Bykahepar (Byk Gulden).
C18H18ClNO4; mol wt 347.79.
C 62.16%, H 5.22%, Cl 10.19%, N 4.03%, O 18.40%.

Description and references

Prepn: K. Klemm et al., DE 1917036; eidem, US 3780095 (1971, 1973 both to Byk-Gulden). Series of articles on synthesis, physical and pharmacological properties: Arzneim.-Forsch. 29, 1-15 (1979). In vitro biochemical study: H. Wolf et al., Biochem. Pharmacol. 29, 1649 (1980). Effect on bile excretion in rats, dogs: P. Berchtold et al., Arzneim.-Forsch. 30, 1878 (1980).

Chemical structure

Properties

Cryst from ethyl acetate, mp 115-116°. pKa 5.04. Soly in water at 37°: 4.02×10-2 mol/l at pH 7. LD50 in rats (mg/kg): >2000 orally; 570 i.v. (Klemm).

Therapeutic Category

Choleretic.

Therapeutic Category (Veterinary)

Choleretic; in treatment of piroplasmosis and anaplasmosis.

Keywords

Choleretic